Average values of physico-chemical parameters for soil and plate-active antimalarials (±standard deviation) vs. plant-only active antimalarials (±standard deviation).
| Parameter | Active on soil and plates | Plate-active only | p-Valuea |
|---|---|---|---|
| Molar mass (g per mole−1) | 351 ± 46 | 360 ± 52 | 0.60 |
| Aromatic atoms (%) | 32 ± 12 | 32 ± 11 | 0.90 |
| Rotatable bond count | 4.6 ± 2 | 5.2 ± 2.5 | 0.42 |
| Hydrogen bond acceptorb | 3.6 ± 1 | 3.0 ± 1.5 | 0.12 |
| Hydrogen bond donorb | 1.2 ± 1 | 1.6 ± 1 | 0.09 |
| Polar surface area (Å2) | 61.5 ± 17 | 54.6 ± 19 | 0.25 |
| log D | 3.6 ± 1 | 3.7 ± 1 | 0.93 |
| log S | −4.3 ± 1 | −4.6 ± 1 | 0.08 |
| log P | 3.5 ± 1 | 4.2 ± 1 | 0.03 |
a
p-Values are given for a two-sample t-test.
b
The hydrogen bond donor and acceptor count are given for pH 7.4. Significant differences at significance level 0.05 is bolded.