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. 2021 Feb 25;11(15):8741–8750. doi: 10.1039/d0ra09934a

The central composition design matrix and experiment results.

Run Independent variables Responses
X 1 X 2 X 3 Y 1 Y 2
1 1 −1 −1 19.84 11.84
2 0 0 −1.68 15.72 9.24
3 1 1 −1 18.40 10.74
4 0 0 0 12.96 7.57
5 0 0 0 13.07 7.67
6 0 0 0 15.38 8.93
7 1.68 0 0 16.96 9.69
8 0 0 1.68 14.00 8.05
9 0 −1.68 0 17.44 10.13
10 0 0 0 13.30 7.76
11 −1.68 0 0 9.11 5.34
12 −1 1 1 13.52 7.89
13 1 −1 1 14.69 8.41
14 0 0 0 15.32 8.91
15 −1 −1 −1 12.92 7.51
16 −1 1 −1 13.44 7.80
17 1 1 1 16.42 9.49
18 0 1.68 0 17.78 10.40
19 −1 −1 1 12.01 7.06
20 0 0 0 13.26 7.84