Composition, encapsulation efficiencies, particle size and zeta potential values of gelatin nanoparticulate formulations.
Code | Gelatin (g) | Stabilizer | Gelatin: stabilizer ratio (w/w) | Solvent, water (mL) | Non-solvent, ethanol (mL) | NP formed | EE% ± SD | PS (nm) ± SD | ZP (mV) | |
---|---|---|---|---|---|---|---|---|---|---|
Poloxamer 407 (g) | Poloxamer 188 (g) | |||||||||
G1 | 0.2 | 1.6 | 0 | 1 : 8 | 10 | 80 | + | 51.68 ± 2.34 | 274.7 ± 30.5 | −10.7 |
G2 | 0.2 | 3.2 | 0 | 1 : 16 | 10 | 80 | + | 63.76 ± 2.38 | 290.0 ± 13.66 | −12.3 |
G3 | 0.2 | 6.4 | 0 | 1 : 32 | 10 | 80 | + | 51.68 ± 2.34 | 274.7 ± 30.5 | −10.7 |
G4 | 0.2 | 1.6 | 0 | 1 : 8 | 10 | 40 | − | — | — | — |
G5 | 0.2 | 3.2 | 0 | 1 : 16 | 10 | 40 | + | — | — | — |
G6 | 0.2 | 6.4 | 0 | 1 : 32 | 10 | 40 | + | — | — | — |
G7 | 0.2 | 0 | 1.6 | 1 : 8 | 10 | 80 | + | 32.65 ± 5.39 | 591.1 ± 37.97 | −10.0 |
G8 | 0.2 | 0 | 3.2 | 1 : 16 | 10 | 80 | + | 41.80 ± 2.12 | 461.1 ± 47.83 | −10.5 |
G9 | 0.2 | 0 | 6.4 | 1 : 32 | 10 | 80 | + | 49.48 ± 3.59 | 458.7 ± 53.95 | −14.8 |
G10 | 0.2 | 0 | 1.6 | 1 : 8 | 10 | 40 | − | — | — | — |
G11 | 0.2 | 0 | 3.2 | 1 : 16 | 10 | 40 | − | — | — | — |
G12 | 0.2 | 0 | 6.4 | 1 : 32 | 10 | 40 | − | — | — | — |