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. 2021 Feb 23;11(14):8398–8410. doi: 10.1039/d0ra09606g

Composition, encapsulation efficiencies, particle size and zeta potential values of gelatin nanoparticulate formulations.

Code Gelatin (g) Stabilizer Gelatin: stabilizer ratio (w/w) Solvent, water (mL) Non-solvent, ethanol (mL) NP formed EE% ± SD PS (nm) ± SD ZP (mV)
Poloxamer 407 (g) Poloxamer 188 (g)
G1 0.2 1.6 0 1 : 8 10 80 + 51.68 ± 2.34 274.7 ± 30.5 −10.7
G2 0.2 3.2 0 1 : 16 10 80 + 63.76 ± 2.38 290.0 ± 13.66 −12.3
G3 0.2 6.4 0 1 : 32 10 80 + 51.68 ± 2.34 274.7 ± 30.5 −10.7
G4 0.2 1.6 0 1 : 8 10 40
G5 0.2 3.2 0 1 : 16 10 40 +
G6 0.2 6.4 0 1 : 32 10 40 +
G7 0.2 0 1.6 1 : 8 10 80 + 32.65 ± 5.39 591.1 ± 37.97 −10.0
G8 0.2 0 3.2 1 : 16 10 80 + 41.80 ± 2.12 461.1 ± 47.83 −10.5
G9 0.2 0 6.4 1 : 32 10 80 + 49.48 ± 3.59 458.7 ± 53.95 −14.8
G10 0.2 0 1.6 1 : 8 10 40
G11 0.2 0 3.2 1 : 16 10 40
G12 0.2 0 6.4 1 : 32 10 40