Fig. 1.

IC50 concentration of GPM induces 1081 DEGs in HUVECs. (A) HUVECs were exposed to various concentrations of GPM for 24 h. Cell viability was measured by WST-1 assay. (B) Images were acquired after 24 h exposure to DMSO (solute control) and GPM IC50. (C) Volcano plot of DEGs between GPM-exposed and DMSO-exposed HUVECs. |Fold change| > 3 and P < 0.05 were used as the threshold for significant differences in gene expression. Red dots: significantly up-regulated genes; green dots: significantly down-regulated genes (D) Numbers of up- or down-regulated genes in HUVECs exposed to GPM. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)