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Fig. 6. The cytotoxicity of normal HEK293T and malignant MCF-7 cells treated with the various nanoprobes by Cell Counting Kit-8 assay. Data are means ± SD (n = 3 experimental replicates). **P < 0.01 versus normal cells, ***P < 0.001 versus normal cells by t-test. (a) Untreated cells, (b) cells treated with unloaded DNA-hybrid-gated UCNP@UIO-66-NH2, (c) cells treated with DNA-hybrid-gated UCNP@UIO-66-NH2/DOX without modified AS1411, (d) cells treated with DNA-hybrid-gated UCNP@UIO-66-NH2/DOX with modified AS1411.