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. 2021 Dec 9;11:762946. doi: 10.3389/fonc.2021.762946

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Copyright © 2021 Ren, Hu, Li, Chen, Ding, Zu and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NR2C2 is negatively correlated with miR-616-5p and inhibits bladder cancer cell invasion and migration. (A) Western blot assay for screening the downstream target genes in T24 cells transduced with pLKO and miR-616-5p inhibitor and UMUC3 cells transduced with pLKO and oemiR-616-5p. (B) Correlation between miR-616 and NR2C2 expression in bladder cancer according to LinkedOmics database. (C) Western blot assay for NR2C2 expression in T24 cells transduced with pLKO and shNR2C2 and UMUC3 cells transduced with pWPI and oeNR2C2. (D) Chamber–transwell invasion and wound healing migration assays performed in T24 cells transduced with pLKO and shNR2C2 and UMUC3 cells transduced with pWPI and oeNR2C2. For (C), quantification data are presented as mean ± SD, and significant differences are indicated by **P < 0.01, and ***P < 0.001 compared to the controls.