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. 2021 Dec 9;11:762946. doi: 10.3389/fonc.2021.762946

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Copyright © 2021 Ren, Hu, Li, Chen, Ding, Zu and Fan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-616-5p promotes bladder cancer cell invasion and migration via downregulating the NR2C2 expression. (A) Chamber–transwell invasion and wound healing migration assays performed in T24 cells transduced with pLKO + pLKO, miR-616-5p inhibitor + pLKO, pLKO + shNR2C2, and miR-616-5p inhibitor + shNR2C2. (B) Chamber–transwell invasion and wound healing migration assays performed in UMUC3 cells transduced with pWPI + pWPI, oemiR-616-5p + pWPI, pLKO + oeNR2C2, and oemiR-616-5p + oeNR2C2. All quantification data are presented as mean ± SD, and significant differences are indicated by *P < 0.05, **P < 0.01, and ***P < 0.001 compared to the controls.