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. 2021 Dec 9;11:752331. doi: 10.3389/fonc.2021.752331

Figure 3.

Figure 3

Optimal timing of chemotherapy delays onset of neurological symptoms in 4T1-BR5 murine model of BMBC. (A) Administration of paclitaxel at ZT17 (i.e., TC-ZT17, n=13) prolonged the onset of neurological symptoms relative to mice harboring BMBC and receiving paclitaxel injections at ZT0 (i.e., TC-ZT0, n=13). Additionally, mice harboring BMBC and receiving paclitaxel injections at ZT17 demonstrated significantly prolonged (B) mean and (C) median number of days until the onset of neurological symptoms relative to ZT0. The data are presented as mean +SEM for (B) and median +95% CI for (C). Graph bars that do not share a letter are statistically significantly different at p<0.05. * Log-rank p<0.05. (A) Log-rank test (B) unpaired t-test (C) Mann Whitney test.