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. 2021 Dec 9;11:752331. doi: 10.3389/fonc.2021.752331

Figure 4.

Figure 4

Timing of Paclitaxel Administration Does Not Alter Sleep/Wake States in Mice Harboring JIMT-1BR3 BMBC. Sleep/Wake states did not significantly differ between (A) baseline, (B) three days following the first paclitaxel injection, or (C) three days following the second paclitaxel injection. There was an unexpected power outage following the first paclitaxel injection, day 1 ZT4-8. Additionally, whereas in both groups there was an increase in (D) total sleep, (E) sleep during the daytime, and (F) sleep during the nighttime in the three days following the second paclitaxel injection relative to baseline sleep, these effects were not specific to one group. Further, there was no change in the (G) diurnal ratio between groups. (A–C). n= 8,7 respectively; (D–F). n= 8,6 respectively; (G) n=7,5 respectively). The data are presented as mean +SEM. (A, B) Two-way repeated measures ANOVA; Fisher’s LSD multiple comparisons test. (C) Mixed effect analysis; Fisher’s LSD multiple comparisons test. (D–G) unpaired t-test.