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. 2021 Mar 1;11(16):9130–9221. doi: 10.1039/d0ra09759d

I2-mediated sulfenylation and sulfonylation of 2-naphthols with sodium sulfinates.

graphic file with name d0ra09759d-u68.jpg
Thioethers Method-A Sulfones Method-B
graphic file with name d0ra09759d-u69.jpg R = H: 80% graphic file with name d0ra09759d-u70.jpg R = H: 82%
R = F: 70% R = F: 73%
R = Br: 75% R = Br: 77%
R = Cl: 75% R = Cl: 75%
R = Me: 89% R = Me: 84%
R = CF3: 71% R = CF3: 67%
R = OMe: 85% R = OMe: 72%
R = OCF3: 66% R = OCF3: 70%
graphic file with name d0ra09759d-u71.jpg R = Me: 60% graphic file with name d0ra09759d-u72.jpg R = Me: 68%
R = n-Pr: 80% R = n-Pr: 45%