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. 2021 Dec 9;15:774050. doi: 10.3389/fnins.2021.774050

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Copyright © 2021 Shevchouk, Tufvesson-Alm and Jerlhag.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustrations of brain regions important for the interaction between the GLP-1 pathway and addiction processes. GLP-1R agonists attenuate behaviors relating to reward and intake of alcohol (Alc), nicotine (Nic), cocaine (Coc) and oxycodone (Oxy). Nucleus tractus solitarii (NTS) of the brain stem, ventral tegmental area (VTA), nucleus accumbens (NAc) shell, laterodorsal tegmental area (LDTg), basolateral amygdala (BLA), lateral septum (LS) and hippocampus (HIP), paraventricular nucleus (PVN), arcuate nucleus (ARC) and lateral hypothalamus (LH) and interpeduncular nucleus (IPN). ↓ Shows an attenuation and Ø reflects no change. *Role shown indirectly.