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. 2021 Dec 9;15:774050. doi: 10.3389/fnins.2021.774050

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Copyright © 2021 Shevchouk, Tufvesson-Alm and Jerlhag.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustration of the different phases of the addiction cycle which amylin signaling influence. Amylin or amylin receptor agonists influence behaviors of the addiction cycle, related to alcohol (Alc), nicotine (Nic), Amphetamine (Amph) or cocaine (Coc). Positive association (+), decreases/attenuates (↓), conflicting evidence or no effect (Ø) on drug effect. Dopamine release in nucleus accumbens (DA), locomotor stimulation (LMA), reward of conditioned place preference (rCPP), memory of alcohol reward in the CPP test (mCPP), motivation (FR, and PR), Alcohol and drug intake (Intake), functional magnetic resonance (fMRI).