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. 2021 Dec 23;27(4):1062–1076. doi: 10.1016/j.drudis.2021.12.014

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© 2021 Elsevier Ltd. All rights reserved.

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

PMC Copyright notice

Development of advanced technology in drug screening. Given limitations of animal research, using novel and more practical strategies appears imperative. To this end, chip platforms [from organ-on-chip (OoC) to human-on-chip (HoC)] have been progressed extensively to emulate the complicated characteristics of human body and provide a more reliable platform in the translational clinical setting. Human lung-on-chip and gut-on-chip are two examples of such advanced technology that have been used in COVID-19 studies. OoC/HoC technology offers great opportunities for high-throughput screening of candidate drugs.