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Prefrontal local circuit. Glutamatergic afferents innervate both excitatory pyramidal neurons (PN) and inhibitory GABAergic IN subtypes 248. These inputs are capable to generate diverse feedforward control on the prefrontal local network through PV-, SST, or VIP-INs. PV-INs express relatively low levels of NMDARs 51, 94–98, and they are enriched with GluN2A subunit 99–101. In contrast, SST- and VIP-INs express relatively more NMDARs and are enriched with GluN2B subunits 102–104.
