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. Author manuscript; available in PMC: 2022 Mar 31.
Published in final edited form as: Mol Psychiatry. 2021 Jun 23;27(1):731–743. doi: 10.1038/s41380-021-01196-w

Figure 3.

Figure 3.

Schematic model showing the development of NMDAR subunits in different types of PFC neurons. Layer II/III pyramidal neurons (PN) exhibit equal amount of GluN2A and GluN2B subunits, whereas layer V pyramidal neurons expresses more GluN2B subunits during the juvenile to adulthood development. In contrast, in the GABAergic interneurons (non-pyramidal neurons (NP), fast-spiking (FS) interneurons exhibits clear GluN2B-to-GluN2A subunit switch whereas regular spiking (RS) and low-threshold spiking (LTS) interneurons exhibit similar NMDAR subunit expression to the layer II/III pyramidal neurons. In summary, except a subset of FS-NPs, which show a sharp increase of GluN2A and decrease of GluN2B, all other cells exhibit no GluN2B-to-GluN2A switch during postnatal development, differing from other brain regions 95, 155, 185, 249.