Table 2.
Percentage of high-risk patients by individual markers at baseline in the total population, death, and survival groups.
| Markers | Threshold (high risk) | Percentage in death group n (%) | Percentage in survival group n (%) | p-value | FDR |
|---|---|---|---|---|---|
| Cardiac stretch | |||||
| NT-proBNP | >8.0 pg/mL | 50 (49.0) | 46 (16.6) | <0.001 | <0.001 |
| Cardiomyocyte injury | |||||
| Hs-TnT, N (%) | >13.3 ng/L | 91 (89.2) | 186 (66.9) | <0.001 | <0.001 |
| Inflammation | |||||
| Hs-CRP | >3.7 mg/L | 73 (71.6) | 152 (54.7) | 0.003 | 0.007 |
| GDF-15 | >6.9 ng/mL | 29 (28.4) | 28 (10.1) | <0.001 | <0.001 |
| MCP-1 | <445.6 pg/mL | 47 (46.1) | 95 (34.2) | 0.034 | 0.042 |
| TNFα | >28.2 pg/mL | 70 (68.6) | 169 (60.8) | 0.161 | 0.161 |
| sTNFRI | >2.17 ng/mL | 53 (52.0) | 102 (36.7) | 0.007 | 0.013 |
| sTNFRII | >14.9 ng/mL | 33 (32.4) | 54 (19.4) | 0.008 | 0.013 |
| Endothelial function | |||||
| Endoglin | >3.21 ng/mL | 46 (45.1) | 85 (30.6) | 0.008 | 0.013 |
| Extracellular matrix turnover | |||||
| TIMP-1 | >72.0 ng/mL | 99 (97.1) | 229 (82.4) | <0.001 | <0.001 |
| TIMP-2 | >44.5 ng/mL | 92 (90.2) | 222 (79.9) | 0.018 | 0.027 |
| MMP-2 | >290.7 ng/mL | 39 (38.2) | 63 (22.7) | 0.002 | 0.006 |
| MMP-8 | <11.8 ng/mL | 93 (91.2) | 234 (84.2) | 0.081 | 0.085 |
| MMP-9 | >133.5 ng/mL | 81 (79.4) | 180 (64.8) | 0.006 | 0.013 |
| Fibrosis | |||||
| Galectin-3 | >9.26 ng/mL | 84 (82.4) | 181 (65.1) | 0.001 | 0.004 |
| sST2 | >39.1 ng/mL | 21 (20.6) | 32 (11.5) | 0.025 | 0.032 |
| Renal function | |||||
| Lipocanlin-2 | >289.9 ng/mL | 58 (56.9) | 126 (45.3) | 0.046 | 0.055 |
| Cystatin-C | >1,953 ng/mL | 55 (53.9) | 121 (43.5) | 0.072 | 0.08 |
| Ascend_HF score | >5.0 | 76 (74.5) | 146 (52.5) | <0.001 | <0.001 |
NT-proBNP, N-terminal pro B-type brain-type natriuretic peptide; Hs-TNT, high-sensitivity cardiac troponin T; Hs-CRP, high-sensitivity C-reactive protein; GDF-15, growth differentiation factor-15; MCP-1, monocyte chemoattractant protein-1; TNFα, tumor necrosis factor-α; sTNFR, soluble tumor necrosis factor-receptor; TIMP, tissue inhibitor of metalloproteinases; MMP, matrix metalloproteinase; sST2, soluble suppression of tumorigenicity 2; P value <0.05 and FDR <0.05 are shown in bold.