Fig. 3. Location of conserved Tyr and Trp. For most of the PAPs, the Trp belongs to the S1 region (substrate binding region 1) as depicted in PlmII. Whereas in case of BACE1, the Trp is a part of the flap region. Exceptions: PlmV doesn't possess the conserved Trp and in case of PlmIX/X the Tyr is replaced by Phe. The homology modelled structures were generated using SwissModel15 and can be accessed in the corresponding Github profile.
