TABLE 2.

Canonical OXPHOS functions of the mitochondrial complex subunits affected by PD-associated genes in Table 1.

Complex	Subunits*	Functions	Associated PD genes
Complex I	NDUFB8	An accessory subunit of the P module	PRKN, PINK1
	NDUFS2	A core subunit of the Q module	PRKN, PINK1
	NDUFB11	An accessory subunit of the P module	PRKN, PINK1
	NDUFA7	An assembly subunit	PRKN, PINK1
	NDUFV2	A core subunit of N module	PRKN, PINK1
	NDUFA5	An accessory subunit of Q module	PRKN, PINK1
	NDUFA9	An accessory subunit of Q module	PRKN, PINK1
	NDUFA13	An accessory subunit of P module	PRKN, PINK1
	NDUFA8	An accessory subunit of P module	PRKN, PINK1
	NDUFB10	An accessory subunit of P module	PRKN, PINK1
	NDUFS3	A core subunit of the Q module	PRKN, PINK1
	NDUFS1	A core subunit of the N module	PRKN, PINK1, PARK7
	NDUFA10	An accessory subunit of P module	PINK1
	ND1	An core subunit of P module	PARK7
Complex II	SDHB	An enzymatic subunit	PRKN, PINK1
Complex III	UQCRB	Maintaining Cytochrome b stability with UQCRQ	PRKN, PINK1
	UQCRC2	A core subunit of cIII; in situ processing of UQCRFS1 (probable)	PRKN, PINK1
	UQCRC1	A core subunit of cIII; in situ processing of UQCRFS1 (probable)	-
	UQCRFS1	A core subunit of cIII, responsible for transducing electrons from Cytochrome b to Cytochrome c-1	UQCRC1
	CYC1	To reduce cytochrome c	UQCRC1
	UQCRQ	Maintaining Cytochrome b stability with UQCRB	UQCRC1
	UQCR10	Unclear	UQCRC1
	UQCR11	Unclear	UQCRC1
Complex IV	COX5A	Response to hypoxia and regulate NO production	PRKN, PINK1
	COX4I1 and-2	Modulation of oxygen affinity	PRKN, PINK1, CHCHD2
	COX2	To oxidize cytochrome c	PRKN, PINK1
	NDUFA4	CIV maintenance	PARK7
Complex V	ATP5L, 5L2	A subunit of the F0 domain	PRKN, PINK1
	ATP5H, ATP5HL1	A subunit of the F0 domain	PRKN, PINK1
	ATP5F1	A subunit of the F0 domain	PRKN, PINK1
	ATP5PO	A subunit of the F0 domain	PRKN, PINK1
	ATP5F1B	A subunit of the F1 domain	PARK7, SNCA

*All designated by human gene names.