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| |||||
|---|---|---|---|---|---|
| Entry | Solvent | Base | Additive | Yieldb (%) | Eec (%) |
| 1 | CH2Cl2 | K2CO3 | None | 83 | 78 |
| 2 | CH3CN | K2CO3 | None | >99 | 68 |
| 3 | CH2Cl2 | K3PO4 | None | 87 | 80 |
| 4 | CH2Cl2 | K2CO3 | (PhO)2PO2H | 78 | 91 |
All the reactions were carried out on a 0.15 mmol scale of 10.
Isolated yield.
Determined by chiral HPLC.
