TABLE 1.
Function of lncRNAs in reproductive system.
| Gene name | Species and samples | Biological functions | Mechanism | Reference |
|---|---|---|---|---|
| LncRNA HOTTIP | Mouse spermatogonial cell line GC-1 cells | Promote cells G2/M phase arrest and early apoptosis | The expression of γ -H2Ax and p53 was up-regulated by adjacent gene Hoxa13 | Liang and Hu (2019) |
| NONMMUT074098.2 | Mouse spermatogonial cell line GC-1 cells | Apoptosis | Knocking down NONMMUT074098.2 activated the p38 MAPK pathway | Li et al. (2019b) |
| LncRNA AK015322 | Mouse SSC line C18-4 cells | Promote cells proliferation | LncRNA AK015322 sponged miR-19b-3p and alleviated the inhibition of ETV5 | Hu et al. (2017) |
| LncRNA ZFAS1 | Human ovarian granulosa cells(PCOS patients) | Endocrine, proliferation and apoptosis | LncRNA ZFAS1 bound miR-129 to promote the expression level of HMGB1 | Zhu et al. (2020) |
| LncRNA NEAT1 | Ovarian granulosa cells (PCOS rats) | Proliferation and apoptosis | Knockdown LncRNA NEAT1 promoted IGF1 expression via miR-381 | Zhen et al. (2021) |
| LncRNA ROR | Human epithelial ovarian carcinoma cell lines SKOV3 and 3AO cells | Epithelial-mesenchymal transition (EMT) | LncRNA ROR promoted EMT via mir-145/FLNB axis | Li et al. (2019a) |
| LINC00339 | Human epithelial ovarian carcinoma cell lines SKOV3 and HO-8910 cells | Proliferation, migration, and invasion | LINC00339 bound miR-148a-3p to promote the expression level of ROCK1 | Pan et al. (2019) |
| LncRNA SLC7A11-AS1 | Human testicular embryonic carcinoma cells line NCCIT cells | Increased ROS levels | The expression of SLC7A11 was negatively regulated and the oxidative stress level of cells was increased | Sanei-Ataabadi et al. (2020) |
| miR-18b | Human follicular fluid with PCOS | Promoted progesterone release, inhibited testosterone and estradiol release | miR-18b targeted the mRNAs of IL8, SYT1 and IRS2 | Roth et al. (2014) |
| miR-224 | Mouse granulosa cells | Induced GCs proliferation and increased estrogen release | miR-224-mediated target gene Smad4 pathway | Yao et al. (2010a) |
| miR-16 | Human ovarian granulosa cells with PCOS | Proliferation cycle and apoptosis | miR-16 promoted the proliferation and inhibited apoptosis of ovarian GCs by directly targeting PDCD4 | Fu et al. (2018b) |
| miR-141, miR-429 and miR-7-1-3p | Human semen with non-obstructive azoospermia patients | Potential markers of NOA | miR-141 reduced the expression levels of Cbl and Tgfβ2, and miR-7-1-3p down-regulated Rb1 and Pik3r3. | Wu et al. (2013) |