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. 2021 Dec 9;9:760724. doi: 10.3389/fbioe.2021.760724

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Copyright © 2021 Gao, Chen, Sugimoto, Mizuta, Zhou, Kishimoto, Huang and Omori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of genetic and prognostic information of m5C regulators in OSCC. (A) Expression of 16 m5C regulators between OSCC and normal samples. (*p < 0.05; ***p < 0.001). (B) Frequency plots of copy number alteration defined in all m5C regulators. (C) Location of copy number variations of m5C regulators on chromosomes. (D) Waterfall plot of the mutation genes and types of m5C regulators in OSCC. (E) Interaction between m5C regulators in OSCC. (F) Prognostic analyses of m5C regulators by univariate Cox regression test. (G–O) OS analysis of m5C regulators in OSCC patients. m5C, 5-methylcytosine; OSCC, oral squamous cell carcinoma.