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. 2021 Dec 9;9:760724. doi: 10.3389/fbioe.2021.760724

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Copyright © 2021 Gao, Chen, Sugimoto, Mizuta, Zhou, Kishimoto, Huang and Omori.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of m5C-modification cluster-related modules and m5Cscore scoring-system construction. (A) Construction of hierarchical clustering dendrogram. (B) Correlation analysis between modules; the yellow module is most related to the m5C modification cluster. (C) A scatter plot of gene significance versus module membership in the yellow module. (D) Heat map of the expression of m5C phenotype-related genes and related clinical information in OSCC. (E) Comparison of gene expression of m5C regulators between the two m5C gene clusters. (*p < 0.05; ***p < 0.001). (F) OS analysis for OSCC patients within different m5C gene clusters. (G) OS analysis for OSCC patients within different m5C gene clusters in the validation cohort. m5C, 5-methylcytosine; OS, overall survival; OSCC, oral squamous cell carcinoma.