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. 2021 Dec 9;14:779436. doi: 10.3389/fnmol.2021.779436

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Copyright © 2021 Lin, Lan, Zhu, Yu, Wu, Wan, Shu, Xiang, Hou, Zhang, Ma, Su and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of activation or inhibition of D2R-containing neurons in the SNpc on total distance and resting time in the open-field test in mice. (A) Evaluations of the trajectory in the open-field test in mice 30 min after the injection of saline (i.p. Saline) or CNO (i.p. CNO) in the WT + Vehicle + mCherry + i.p. Saline group (WT + m), D2R-cre + Vehicle + mCherry + i.p. Saline group (Veh + m), D2R-cre + IDPN + mCherry + i.p. Saline group (TS + m), D2R-cre + Vehicle + Gq + i.p. Saline group (Veh + Gq), D2R-cre + IDPN + Gq + i.p. Saline group (TS + Gq), D2R-cre + Vehicle + Gi + i.p. Saline group (Veh + Gi), D2R-cre + IDPN + Gi + i.p. Saline group (TS + Gi), WT + Vehicle + mCherry + i.p. CNO group (WT + m), D2R-cre + Vehicle + mCherry + i.p. CNO group (Veh + m), D2R-cre + IDPN + mCherry + i.p. CNO group (TS + m), D2R-cre + Vehicle + Gq + i.p. CNO group (Veh + Gq), D2R-cre + IDPN + Gq + i.p. CNO group (TS + Gq), D2R-cre + Vehicle + Gi + i.p. CNO group (Veh + Gi), D2R-cre + IDPN + Gi + i.p. CNO group (TS + Gi) on day 23. (B) Total distance in the open-field test within 10 min in mice of each group 30 min after the injection of saline (i.p. Saline) on day 23. (C) Total distance in the open-field test within 10 min in mice of each group 30 min after the injection of CNO (i.p. CNO) on day 23. (D) Resting time in the open-field test within 10 min in mice of each group 30 min after the injection of saline (i.p. Saline) on day 23. (E) Resting time in the open-field test within 10 min in mice of each group 30 min after the injection of CNO (i.p. CNO) on day 23. Data are expressed as mean ± SEM (n = 6 mice in each group), and the black line segment indicates the differences between groups, * represents P < 0.05 between marked groups, and n.s. represents P > 0.05 between marked groups.