Table 6.
Median DSC and Median MBD of merged leaflets, and p values for two–sided non–parametric Wilcoxon signed–rank test at individual stages and all stages combined.
| FCN Configuration A | FCN Configuration B | Med. DSC A | Med. DSC B | p Value | Med. MBD A | Med. MBD B | p Value | |
|---|---|---|---|---|---|---|---|---|
| Pre–Stage1 | (Two-Phase) Im-Only-Res | (Two-Phase) Ann-Res | 0.80 [0.77–0.81] | 0.88 [0.87–0.89] | 0.02* | 0.44 [0.41–0.47] | 0.19 [0.17–0.23] | 0.02* |
| (Two-Phase) Im-Only-Res | (Single-Phase) Com-Res | 0.80 [0.77–0.81] | 0.85 [0.84–0.86] | 0.02* | 0.44 [0.41–0.47] | 0.39 [0.27–0.43] | 0.22 | |
| (Two-Phase) Im-Only-Res | (Single-Phase) Ann-Com-Res | 0.80 [0.77–0.81] | 0.89 [0.87–0.89] | 0.02* | 0.44 [0.41–0.47] | 0.18 [0.16–0.21] | 0.02* | |
| (Two-Phase) Ann-Res | (Single-Phase) Com-Res | 0.88 [0.87–0.89] | 0.85 [0.84–0.86] | 0.02* | 0.19 [0.17–0.23] | 0.39 [0.27–0.43] | 0.05* | |
| (Two-Phase) Ann-Res | (Single-Phase) Ann-Com-Res | 0.88 [0.87–0.89] | 0.89 [0.87–0.89] | 0.94 | 0.19 [0.17–0.23] | 0.18 [0.16–0.21] | 0.16 | |
| (Single-Phase) Com-Res | (Single-Phase) Ann-Com-Res | 0.85 [0.84–0.86] | 0.89 [0.87–0.89] | 0.02* | 0.39 [0.27–0.43] | 0.18 [0.16–0.21] | 0.05* | |
| Post–Stage1 | (CSP) Im-Only-Res | (CSP) Ann-Res | 0.70 [0.68–0.75] | 0.83 [0.78–0.84] | 0.03* | 0.66 [0.45–0.84] | 0.35 [0.26–0.38] | 0.02* |
| (CSP) Im-Only-Res | (Single-Phase) Com-Res | 0.70 [0.68–0.75] | 0.75 [0.74–0.76] | 0.03* | 0.66 [0.45–0.84] | 0.54 [0.45–0.63] | 0.08 | |
| (CSP) Im-Only-Res | (CSP) Ann-Com-Res | 0.70 [0.68–0.75] | 0.83 [0.76–0.85] | 0.02* | 0.66 [0.45–0.84] | 0.40 [0.33–0.42] | 0.02* | |
| (CSP) Ann-Res | (Single-Phase) Com-Res | 0.83 [0.78–0.84] | 0.75 [0.74–0.76] | 0.11 | 0.35 [0.26–0.38] | 0.54 [0.45–0.63] | 0.05* | |
| (CSP) Ann-Res | (CSP) Ann-Com-Res | 0.83 [0.78–0.84] | 0.83 [0.76–0.85] | 0.47 | 0.35 [0.26–0.38] | 0.40 [0.33–0.42] | 0.22 | |
| (Single-Phase) Com-Res | (CSP) Ann-Com-Res | 0.75 [0.74–0.76] | 0.83 [0.76–0.85] | 0.08 | 0.54 [0.45–0.63] | 0.40 [0.33–0.42] | 0.08 | |
| Post–Stage2 | (CSP) Im-Only-Res | (CSP) Ann-Res | 0.75 [0.74–0.78] | 0.81 [0.77–0.83] | 0.02* | 0.57 [0.54–0.73] | 0.37 [0.36–0.47] | 0.03* |
| (CSP) Im-Only-Res | (Two-Phase) Com-Res | 0.75 [0.74–0.78] | 0.76 [0.75–0.80] | 0.08 | 0.57 [0.54–0.73] | 0.54 [0.47–0.57] | 0.05* | |
| (CSP) Im-Only-Res | (CSP) Ann-Com-Res | 0.75 [0.74–0.78] | 0.82 [0.79–0.84] | 0.02* | 0.57 [0.54–0.73] | 0.34 [0.33–0.40] | 0.02* | |
| (CSP) Ann-Res | (Two-Phase) Com-Res | 0.81 [0.77–0.83] | 0.76 [0.75–0.80] | 0.02* | 0.37 [0.36–0.47] | 0.54 [0.47–0.57] | 0.05* | |
| (CSP) Ann-Res | (CSP) Ann-Com-Res | 0.81 [0.77–0.83] | 0.82 [0.79–0.84] | 0.11 | 0.37 [0.36–0.47] | 0.34 [0.33–0.40] | 0.02* | |
| (Two-Phase) Com-Res | (CSP) Ann-Com-Res | 0.76 [0.75–0.80] | 0.82 [0.79–0.84] | 0.02* | 0.54 [0.47–0.57] | 0.34 [0.33–0.40] | 0.03* | |
| Post–Stage3 | (CSP) Im-Only | (Two-Phase) Ann-Res | 0.80 [0.76–0.82] | 0.87 [0.86–0.88] | 0.02* | 0.61 [0.47–1.37] | 0.34 [0.30–0.37] | 0.02* |
| (CSP) Im-Only | (CSP) Com-Res | 0.80 [0.76–0.82] | 0.84 [0.82–0.85] | 0.22 | 0.61 [0.47–1.37] | 0.58 [0.47–0.67] | 0.38 | |
| (CSP) Im-only | (Single-Phase) Ann-Com-Res | 0.80 [0.76–0.82] | 0.88 [0.87–0.88] | 0.02* | 0.61 [0.47–1.37] | 0.33 [0.32–0.37] | 0.02* | |
| (Two-Phase) Ann-Res | (CSP) Com-Res | 0.87 [0.86–0.88] | 0.84 [0.82–0.85] | 0.02* | 0.34 [0.30–0.37] | 0.58 [0.47–0.67] | 0.03* | |
| (Two-Phase) Ann-Res | (Single-Phase) Ann-Com-Res | 0.87 [0.86–0.88] | 0.88 [0.87–0.88] | 0.81 | 0.34 [0.30–0.37] | 0.33 [0.32–0.37] | 0.94 | |
| (CSP) Com-Res | (Single-Phase) Ann-Com-Res | 0.84 [0.82–0.85] | 0.88 [0.87–0.88] | 0.02* | 0.58 [0.47–0.67] | 0.33 [0.32–0.37] | 0.02* | |
| All Stages | (CSP) Im-Only | (CSP) Ann-Res | 0.76 [0.71–0.80] | 0.86 [0.81–0.88] | <0.001* | 0.61 [0.50–0.79] | 0.35 [0.23–0.40] | <0.001* |
| (CSP) Im-Only | (Single-Phase) Com-Res | 0.76 [0.71–0.80] | 0.82 [0.75–0.84] | <0.001* | 0.61 [0.50–0.79] | 0.49 [0.40–0.63] | 0.004* | |
| (CSP) Im-Only | (CSP) Ann-Com-Res | 0.76 [0.71–0.80] | 0.85 [0.82–0.88] | <0.001* | 0.61 [0.50–0.79] | 0.33 [0.26–0.40] | <0.001* | |
| (CSP) Ann-Res | (Single-Phase) Com-Res | 0.86 [0.81–0.88] | 0.82 [0.75–0.84] | <0.001* | 0.35 [0.23–0.40] | 0.49 [0.40–0.63] | <0.001* | |
| (CSP) Ann-Res | (CSP) Ann-Com-Res | 0.86 [0.81–0.88] | 0.85 [0.82–0.88] | 0.09 | 0.35 [0.23–0.40] | 0.33 [0.26–0.40] | 0.49 | |
| (Single-Phase) Com-Res | (CSP) Ann-Com-Res | 0.82 [0.75–0.84] | 0.85 [0.82–0.88] | <0.001* | 0.49 [0.40–0.63] | 0.33 [0.26–0.40] | <0.001* |
The best ranked FCN input configurations across individual user inputs were compared. Different stages are presented along the larger row blocks. Metric values are displayed as median [IQR]. No additional user inputs (Im-Only), annular curve input (Ann), commissural landmarks input (Com) and resampling (Res). Significant p values (<0.05) marked with an asteroid (*). Significant differences could be found in almost all pairwise combinations except when comparing the use of input images only with commissural landmarks input only and when comparing the annular curve input only and the annular curve combined with the commissural landmarks. In addition, for post–stage 1 repair, no significant differences could be found when comparing annular curve input only with commissural landmarks input only and when comparing commissural landmarks only with the combination of annular curve and commissural landmarks.