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. 2021 Dec 9;9:783385. doi: 10.3389/fcell.2021.783385

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Copyright © 2021 Liu, Lu, Fang, Sheng, Cui, Yang, Tang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DUXAP8 can regulate the characteristics of migration, invasion, and stemness of HCC cells. (A,C,E) DUXAP8 or shDUXAP8 and the control cells were subjected to Transwell migration and Matrigel invasion assays. (B,D,F) Western blot detects the expression of epithelial–mesenchymal transformation markers in DUXAP8-downregulated Huh7 and SNU-449 cells and DUXAP8-overxpressed SK-Hep-1 cells. (G,I,K) Statistical analysis of the primary and secondary spheroid-forming ability of DUXAP8-downregulated Huh7 and SNU-449 cells and DUXAP8-overexpressed SK-Hep-1 cells, with representative images showing secondary spheroid formation in these cells. (H,J,L) Western blot detects the expression levels of stemness-related genes in DUXAP8-downregulated Huh7 and SNU-449 cells and DUXAP8-overexpressed SK-Hep-1 cells. Data are expressed as mean, *p < 0.05, **p < 0.01.