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. 2021 Dec 9;9:783385. doi: 10.3389/fcell.2021.783385

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Copyright © 2021 Liu, Lu, Fang, Sheng, Cui, Yang, Tang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miR-584-5p targets MAPK1 in HCC. (A) The heat map and volcano plot demonstrating the differentially expressed genes in HCC after DUXAP8 downregulation, and Kyoto Encyclopedia of Genes and Genomes analysis of the main associated pathways. (B) The result of the correlation analysis showing that miR-584-5p was negatively correlated with MAPK1 expression. (C) Dual-luciferase reporter assay detecting the relative activity of luciferase in transfected HCC cells. (D) Effect of miR-584-5p downregulation and overexpression on MAPK1 expression in HCC cells. (E) Effect of down-regulation or overexpression of DUXAP8 and miR-584-5p on MAPK1 expression in HCC during co-transfection. Data are expressed as mean, **p < 0.01.