Table 4.

Main enhancement patterns of malignant focal liver lesions

Tumor	Arterial phase (10-30 s)	Portal venous phase (20-120 s)	Late phase (120-300 s)	Post-vascular phase (>10 min)
Metastasis
Typical features	Rim enhancement	Hypoenhancing	Hypo/nonenhancing	Hypo/nonenhancing
	Hyperenhancement	-	-	-
	Nonenhancing regions	-	-	-
Hepatocellular carcinoma
Typical features	Hyperenhancing	Iso-enhancing	Hypo/nonenhancing	Hypo/nonenhancing
Additional features	Nonenhancing regions	Nonenhancing regions	Nonenhancing regions	Nonenhancing regions
Cholangiocarcinoma
Typical features	Rim-like hyperenhancement, central hypoenhancement	Hypoenhancing	Hypo/nonenhancing	Hypo/nonenhancing
Additional features	Nonenhancing regions	Nonenhancing regions	Nonenhancing regions	Nonenhancing regions
	Inhomogeneous hyperenhancement	-	-	-

Based on the Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) in the Liver [1].