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. 2021 Dec 9;15:786679. doi: 10.3389/fnana.2021.786679

FIGURE 8.

FIGURE 8

Migratory routes of cells originating in the Diagonal area. (A) Rostrocaudal gradient of schematic coronal sections showing the migratory routes of caudoventral MGE/Diagonal area (cvMGE/Dg)-derived cells toward the cortex, striatum and amygdala. At rostral levels, the early-born Dg-derived cells selectively surround the Globus Pallidus (GP), after which cells migrate subventricularly (smaller population, smaller arrow) or superficially toward the striatum and cortex. At more caudal ends of the telencephalon, a presumed radially migrating stream of Sst cells originating in the intraamygdaloid part of the BST (BSTia) passes behind the GP, through the developing CA, thereby connecting to the SSpM laterally. An intraamygdaloid migratory stream tangentially colonizes the pallial amygdala starting from the BSTM(ia), passing the BLA dorsally and caudally, connecting rostrally and dorsolaterally with the LA and caudoventrally with the BMA. A continued migration connects this stream to the AHi (not shown). A migration route from the bed nucleus of the stria terminalis (BST) toward the medial amygdala (MA) is also shown (pink arrow), although this migration route is still controversial. (B) Schematic horizontal section showing the migratory routes of caudoventral MGE/Diagonal area (cvMGE/Dg)-derived cells toward the cortex, striatum and amygdala. The subpial subpallial migratory stream (SSpM) and the subventricular subpallial migratory stream (SvSpM) are marked. In addition to the routes mentioned in panel (A), the AHi is also invaded, either from the SvSpM (shown) or medially from the intraamygdaloid stream (not shown). Str, Striatal domain; Pal, Pallidal domain; Dg, Diagonal Domain; POA, Preoptic Area; BSTL, lateral part of BST; BSTM, Medial part of BST; BSTia, intraamygdaloid part of BST; MA, medial amygdala; CA, Central amygdala; LA, Lateral amygdala; BLA, Basolateral amygdala; BM, Basomedial amygdala; Th, Thalamus; IC, Internal Capsule; GP, Globus Pallidus; SSpM, subpial subpallial migratory stream; SvSpM, subventricular subpallial migratory stream.