Table 1.
Characteristics of the liver macrophage subsets.
| Subsets | Origins | Phenotypes | Properties | Receptors | Functions |
|---|---|---|---|---|---|
| KCs | Yolk sac-derived erythromyeloid progenitors | CD11bloF4/80hi (mice) | Self-renewal | CLEC4F | Strong phagocytosis and efferocytosis |
| CD163L (human) | VSIG4 | ||||
| TIM-4 | |||||
| MDMs | Circulating monocytes | CD11b+F4/80+ (mice) | Differentiate into KCs | High lysozyme 2 | Secrete pro-inflammatory cytokines and fibrogenic cytokines |
| CLEC5A (human) | |||||
| LCMs | Blood monocytes | F4/80+MHCIIhiCX3CR1hi | Detects peritoneal bacteria and promotes neutrophil recruitment |
KCs, Kupffer cell; MDMs, mononuclear-derived macrophages; LCMs, liver capsular macrophages; CLEC4F, C-type lectin domain family 4 member F; VSIG4, V-set and Ig domain-containing 4; TIM-4, T cell immunoglobulin- and mucin-domain-containing molecule.