Figure 8.

(A) Signaling network comparing miRNA expression values and their target regulation between patients with community acquired pneumonia of bacterial origin (n=12, baseline) and patients with COVID-19 pneumonia (n=15). (B) Network resulting from a comparison between patients with sepsis induced lung injury of bacterial origin (n=28, baseline) and patients with COVID-19 ARDS (n=15) at admission to the ICU (day 0 of treatment). Downregulated miRNAs are shown in green and the corresponding mRNA targets in orange colour. Upregulated miRNAs are marked in red and their inhibited targets in blue. For miRNA target scanning, data were filtered for antimicrobial response and lung as an organ system and confidence levels were set to experimentally observed. Yellow lines and non-coloured molecules indicate undetermined regulatory effects because the transcripts were targeted by miRNAs with different directions of regulation. Solid lines indicate direct and dashed lines indirect relationships. The legend inserted into the graph illustrates the type of target molecules according to the symbols used in the graph.