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. 2021 Dec 9;12:783946. doi: 10.3389/fphar.2021.783946

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Copyright © 2021 Hou, Ding, Du, Yu, Zhou, Cui and Nie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Myc and ribosome proteins were enriched in basal cells. (A) Top 10 enriched pathways of specifically expressed genes in basal cells. Numbers in x-axis represent the genes enriched in the corresponding pathway. P adjust (p. adj) varies from .01 to 0.05. (B) Top 40 ribosome proteins among different cell types. The red and bold font marked genes were closely associated with EMT. (C) Myc in different airway epithelial cells. ^*** p. adj <.001. (D) Heterogeneously expressed Myc mRNA in different airway epithelial cell types after LLI culture. ^*** p < .001 compared with the other cells in corresponding group. ^### p < .001, compared with ALI group within the same cell type. n = 3. One-way ANOVA followed by Bonferroni’s test was used to analyze the difference of the means for significance. (E) Expression of Myc mRNA in ALI and LLI group. ^*** p < .001, compared with ALI group, n = 3. Student’s t-test was used to analyze the difference of the means. (F–G) Representative and statistical data of c-Myc. ^** p < .01, compared with ALI group, n = 4. Mann–Whitney U test was used to analyze the difference of the means for significance.