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. 2021 Dec 9;12:783946. doi: 10.3389/fphar.2021.783946

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Copyright © 2021 Hou, Ding, Du, Yu, Zhou, Cui and Nie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CX-5461 abrogated hypoxia-induced EMT. (A) rRNA expression level after administration of 100 nM CX-5461 in the mode of LLI culture. ^** p < .01, compared with ALI group, ^# p < .05 compared with LLI group, n = 5. Mann–Whitney U test was used to analyze the difference of the means for significance. (B) Expression of E-cadherin, Vimentin, and α-SMA. ^* p < .05, ^*** p < .001, compared with ALI group, ^# p < .05, ^## p < .01, ^### p < .001, compared with LLI group, n = 3. (C–D) Representative and statistical data of EMT markers. ^** p < .01, ^*** p < .001 compared with ALI group, ^## p < .01, ^### p < .001, compared with LLI group, n = 3–4. One-way ANOVA followed by Bonferroni’s test was used to analyze the difference of the means for significance. (E) HE staining. The nether line of images was enlarged from the upper original image. (F) Immunofluorescence of Vimentin (green). The nucleus was stained with DAPI (blue). Scale bar = 50 μm.