Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The schematic diagram of hypoxia-induced EMT in MTECs. Hypoxia enhanced the ribosome biogenesis by increasing the expression of Myc. Subsequently, the phosphorylation of mTOR at Ser2481 was upregulated, and phosphorylation of AKT significantly increased, which promotes the occurrence of the EMT process. CX-5461 suppressed hypoxia-induced EMT by inhibiting the ribosome biogenesis. The red line denotes the repression effects, and the blue line indicates the facilitation effect.
