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Summary of affinities (kD) and association (kon) and dissociation constants (koff and coefficient of determination R2) determined by BLI (left side) and EC50 values of flow cytometry (right side).
| Dissociation constant KD | kon (105 M-1 s-1) | koff (10-4 s-1) | R2 | EC50 | |
|---|---|---|---|---|---|
| CD4-Nb1 | 5.1 nM | 1.21 ± 0.022 | 6.13 ± 0.27 | 0.996 | 0.74 nM |
| CD4-Nb2 | 6.5 nM | 1.22 ± 0.015 | 7.95 ± 0.18 | 0.998 | 0.73 nM |
| CD4-Nb3 | 75.3 nM | 0.82 ± 0.026 | 61.8 ± 2.00 | 0.983 | 533 nM |
| CD4-Nb4 | 135 nM | 1.18 ± 0.014 | 160 ± 0.97 | 0.998 | 7.36 µM |
