TABLE 1.

Net reclassification improvement (NRI) of the developed polygenic risk score and family history in predicting the risk of PCa

Population	No. of subjects	Five‐year risk		Ten‐year risk
		NRI for PRS (95% CI)	NRI for family history (95% CI)	NRI for PRS (95% CI)	NRI for family history (95% CI)
PCa cases	4,832	0.294 (0.283 to 0.324)	−0.711 (−0.731 to −0.686)	0.266 (0.234 to 0.277)	−0.717 (−0.731 to −0.659)
Non‐cases	142,869	0.419 (0.411 to 0.435)	0.84 (0.837 to 0.841)	0.423 (0.400 to 0.434)	0.842 (0.824 to 0.844)
Full population	147,701	0.713 (0.697 to 0.756)	0.129 (0.109 to 0.151)	0.690 (0.649 to 0.705)	0.125 (0.113 to 0.165)

The NRI (in continuous case) of 5‐ and 10‐year risk was calculated by adding the PRS or family history to the baseline model.

PCa, prostate cancer; CI, confidence interval.