TABLE 2.
The diagnostic value of other miRNAs for pancreatic cancer diagnosis
| miRNA | Pancreatic cancer group vs. control group | AUC (95% CI) | SEN (%) | SPE (%) | AUC (+ CA19‐9) (95% CI) | SEN (+ CA19‐9) (%) | SPE (+ CA19‐9) (%) |
|---|---|---|---|---|---|---|---|
| miR‐16+miR‐196a [138] | PC vs. HC | 0.90 (0.85–0.94) | 87.0 | 73.5 | 0.98 (0.96–1.00) | 92.0 | 95.6 |
| miR‐1290 [139] | PC vs. HC | 0.96 (0.91–1.00) | 88.0 | 84.0 | 0.86 (NA)* | 71.0* | 90.0* |
| miR‐1290 [140] | PC vs. HC | 0.93 (0.89–0.97) | 75.0 | 97.5 | 0.99 (0.97–1.00) | 94.2 | 97.5 |
| miR‐1246 [140] | PC vs. HC | 0.85 (0.79–0.91) | 62.5 | 92.5 | 0.96 (0.93–0.99) | 89.2 | 97.5 |
| miR‐1290+ miR‐1246 [140] | PC vs. HC | ND | ND | ND | 0.99 (0.98–1.00) | 96.7 | 97.5 |
| miR‐223 [141] | PC vs. HC | 0.83 (NA) | 62.0 | 94.1 | ND | ND | ND |
| miR‐5100+ miR‐8073+ miR‐642b‐3p+ miR‐663a [142] | PC vs. HC | 0.98 (NA) | 98.6 | 87.5 | ND | ND | ND |
| miR‐21‐5p [143] | PC vs. HC | 0.78 (0.66‐0.90) | 77.0 | 80.0 | ND | ND | ND |
| miR‐133a [144] | PC vs. HC | 0.89 (NA) | 87.2 | 90.6 | ND | ND | ND |
*
The AUC, sensitivity and specificity of CA19‐9 alone in the detection of pancreatic cancer.
Abbreviations: PC: Pancreatic cancer; HC: Healthy controls; ND: not described; NA: not applicable.