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. Author manuscript; available in PMC: 2021 Dec 23.
Published in final edited form as: J Control Release. 2020 Mar 16;322:64–80. doi: 10.1016/j.jconrel.2020.03.020

Fig. 7.

Fig. 7.

Enhanced vascular permeability and intratumoral drug delivery of renal clearable AuNP-based DDS. (A) From the confocal microscopy imaging, renal clearable DDS-5 showed increased tumor accumulation and intratumoral diffusion in TME compared with non-renal clearable DDS-30 within 12 h post-injection. (B-D) With the quantitative analysis of cell percentage (cell%) interacting with DOX across different distances from tumor blood vessels, renal clearable DDS-5 showed much greater accumulation and deeper penetration versus non-renal clearable DDS-30. This was primarily due to the unique strengths of the DDS-5, the ultrasmall size and ultrahigh vascular permeability, for the rapid tumor targeting and efficient drug delivery, ref. [119].