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. 2021 Dec 6;9:695723. doi: 10.3389/fcell.2021.695723

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Copyright © 2021 Madrigal, Hernández-Monge, Herrera, González-De la Rosa, Domínguez-Gómez, Candelaria, Luna-Maldonado, Calderón González and Díaz-Chávez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of miRNAs processing by Mutant p53. Mutants of p53 hinder the association between RNA helicases p72/82 and the microprocessor complex (DROSHA-DGCR8), thereby inhibiting miRNAs' maturation post-transcriptional level. Camptothecin induces acetylation of K120 within the DNA Binding Domain of p53, which augments its association with p72/p82. Whether this drug may revert the poor association of p53 mutants with p72/p82 is not known. p53R273H inhibits the transcription of DICER mRNA through both direct and indirect inhibition of transactivation of TA-p63.