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. 2021 Dec 9;12:790469. doi: 10.3389/fimmu.2021.790469

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Copyright © 2021 Zhang, Poorbaugh, Dougan, Chen, Gottlieb, Huhn, Beasley, Daniels, Ngoc Vy Trinh, Crisp, Freitas, Vaillancourt, Patel, Nirula, Kallewaard, Higgs and Benschop

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The natural history relationship between viral load at baseline (x-axis) and the fold change in antibody titer against the full-length spike (top panel) and NCP (bottom panel) from baseline to day 3, 15, 29, 60, and 85 in the placebo cohort. 42% and 54% of patients were sero-negative at both baseline and day 3 for full-length spike and NCP, respectively. r is the spearman correlation between viral load and log of titer fold change from baseline; p is the p-value associated with spearman correlation test.