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. 2021 Apr 7;11(22):13061–13076. doi: 10.1039/d1ra01588e

One-pot synthesis of β-Thiol-1,4-disubstituted-1,2,3-triazoles from thiiranes catalyzed by nano-MgFe2O4/Cua.

Entry Thiirane (a) Alkyne Triazole (b) Time (h) Yieldb (%)
1 graphic file with name d1ra01588e-u13.jpg graphic file with name d1ra01588e-u14.jpg graphic file with name d1ra01588e-u15.jpg 2.5 96
2 graphic file with name d1ra01588e-u16.jpg graphic file with name d1ra01588e-u17.jpg graphic file with name d1ra01588e-u18.jpg 2 91
3 graphic file with name d1ra01588e-u19.jpg graphic file with name d1ra01588e-u20.jpg graphic file with name d1ra01588e-u21.jpg 2.5 80
4 graphic file with name d1ra01588e-u22.jpg graphic file with name d1ra01588e-u23.jpg graphic file with name d1ra01588e-u24.jpg 4 95
5 graphic file with name d1ra01588e-u25.jpg graphic file with name d1ra01588e-u26.jpg graphic file with name d1ra01588e-u27.jpg 3 90
6 graphic file with name d1ra01588e-u28.jpg graphic file with name d1ra01588e-u29.jpg graphic file with name d1ra01588e-u30.jpg 2 94
7 graphic file with name d1ra01588e-u31.jpg graphic file with name d1ra01588e-u32.jpg graphic file with name d1ra01588e-u33.jpg 2.5 90
8 graphic file with name d1ra01588e-u34.jpg graphic file with name d1ra01588e-u35.jpg graphic file with name d1ra01588e-u36.jpg 2 80
9 graphic file with name d1ra01588e-u37.jpg graphic file with name d1ra01588e-u38.jpg graphic file with name d1ra01588e-u39.jpg 3 92
10 graphic file with name d1ra01588e-u40.jpg graphic file with name d1ra01588e-u41.jpg graphic file with name d1ra01588e-u42.jpg 3.5 90
11 graphic file with name d1ra01588e-u43.jpg graphic file with name d1ra01588e-u44.jpg graphic file with name d1ra01588e-u45.jpg 2.5 95
a

All reactions were carried out with 1 mmol of thiirane in the presence of alkyne (1 mmol), sodium azide (1.2 mmol) and nano-MgFe2O4/Cu (0.02 g) in water at 60 °C.

b

Yields refer to isolated pure products.