One-pot synthesis of β-Thiol-1,4-disubstituted-1,2,3-triazoles from thiiranes catalyzed by nano-MgFe2O4/Cua.
| Entry | Thiirane (a) | Alkyne | Triazole (b) | Time (h) | Yieldb (%) |
|---|---|---|---|---|---|
| 1 |
|
|
|
2.5 | 96 |
| 2 |
|
|
|
2 | 91 |
| 3 |
|
|
|
2.5 | 80 |
| 4 |
|
|
|
4 | 95 |
| 5 |
|
|
|
3 | 90 |
| 6 |
|
|
|
2 | 94 |
| 7 |
|
|
|
2.5 | 90 |
| 8 |
|
|
|
2 | 80 |
| 9 |
|
|
|
3 | 92 |
| 10 |
|
|
|
3.5 | 90 |
| 11 |
|
|
|
2.5 | 95 |
All reactions were carried out with 1 mmol of thiirane in the presence of alkyne (1 mmol), sodium azide (1.2 mmol) and nano-MgFe2O4/Cu (0.02 g) in water at 60 °C.
Yields refer to isolated pure products.