One-pot synthesis of β-Thiol-1,4-disubstituted-1,2,3-triazoles from thiiranes catalyzed by nano-MgFe2O4/Cua.
| Entry | Thiirane (a) | Alkyne | Triazole (b) | Time (h) | Yieldb (%) | 
|---|---|---|---|---|---|
| 1 |   |   |   | 2.5 | 96 | 
| 2 |   |   |   | 2 | 91 | 
| 3 |   |   |   | 2.5 | 80 | 
| 4 |   |   |   | 4 | 95 | 
| 5 |   |   |   | 3 | 90 | 
| 6 |   |   |   | 2 | 94 | 
| 7 |   |   |   | 2.5 | 90 | 
| 8 |   |   |   | 2 | 80 | 
| 9 |   |   |   | 3 | 92 | 
| 10 |   |   |   | 3.5 | 90 | 
| 11 |   |   |   | 2.5 | 95 | 
All reactions were carried out with 1 mmol of thiirane in the presence of alkyne (1 mmol), sodium azide (1.2 mmol) and nano-MgFe2O4/Cu (0.02 g) in water at 60 °C.
Yields refer to isolated pure products.