Table I.
Serum chemistry values at baseline (Day 0) and at end of study period (Day 28).
| Day 0 | Day 14 | Day 28 | |||
|---|---|---|---|---|---|
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| Variable | Median (range) | Median (range) | Median (range) | Reference interval | P-value |
| Glucose (mg/dL) | 337 (318 to 652) | 140 (87 to 285) | 164 (87 to 274) | 70 to 120 | 0.0193 |
| BUN (mg/dL) | 38 (22 to 39) | 40 (24 to 49) | 39 (27 to 48) | 15 to 33 | 0.2466 |
| Creatinine (mg/dL) | 0.9 (0.6 to 1.3) | 0.9 (0.8 to 1.4) | 0.9 (0.8 to 1.6) | 0.9 to 2.1 | 0.2122 |
| Phosphorus (mg/dL) | 4.3 (3.8 to 5.4) | 5.4 (4.3 to 6.0) | 5.2 (4.1 to 5.6) | 3.0 to 6.3 | 0.1653 |
| Calcium, total (mg/dL) | 10.3 (9.5 to 10.8) | 10.6 (10.3 to 11.9) | 10.8 (10.3 to 11.6) | 8.8 to 12.0 | 0.0429 |
| Total protein (g/dL) | 7.8 (6.8 to 8.8) | 8.5 (7.4 to 8.9) | 8.1 (7.0 to 9.4) | 6.0 to 8.4 | 0.0907 |
| Albumin (g/dL) | 3.8 (3.0 to 4.0) | 4.2 (3.5 to 4.9) | 3.9 (3.7 to 4.6) | 2.2 to 4.0 | 0.0743 |
| Globulin (g/dL) | 4.0 (2.8 to 5.8) | 3.6 (3.2 to 5.4) | 3.7 (3.2 to 5.6) | 2.5 to 5.8 | 0.7047 |
| Sodium (mEq/L) | 147 (141 to 151) | 151 (144 to 162) | 153 (146 to 153) | 146 to 158 | 0.2466 |
| Potassium (mEq/L) | 4.6 (4.4 to 5.0) | 4.3 (3.6 to 4.8) | 4.2 (4.1 to 5.3) | 3.4 to 5.2 | 0.2466 |
| Anion gap (mEql/L) | 20 (17 to 25) | 23 (21 to 32) | 23 (20 to 34) | 9 to 21 | 0.0474 |
| Total bilirubin (mg/dL) | 0 (0 to 0.1) | 0 (0 to 0.1) | 0 (0 to 0.1) | 0.1 to 0.3 | 0.8607 |
| ALP (U/L) | 53 (28 to 119) | 36 (17 to 83) | 28 (17 to 78) | 10 to 79.0 | 0.0193 |
| GGT (U/L) | 0 (0 to 1) | 0 (0 to 0) | 0 (0 to 1) | 0 to 5 | 0.6376 |
| ALT (U/L) | 40 (28 to 158) | 53 (35 to 127) | 47 (34 to 168) | 25 to 145 | 0.5488 |
| AST (U/L) | 18 (11 to 55) | 26 (10 to 35) | 28 (10 to 43) | 5.0 to 42 | 0.3867 |
| Creatinine kinase (U/L) | 110 (95 to 153) | 143 (82 to 384) | 92 (84 to 287) | 14 to 528 | 0.8187 |
| Cholesterol (mg/dL) | 221 (169 to 256) | 244 (230 to 394) | 281 (204 to 436) | 77 to 258 | 0.5488 |
| Triglycerides (mg/dL) | 195 (55 to 817) | 108 (40 to 4277) | 147 (125 to 7140) | 25 to 191 | 0.1738 |
BUN — blood urea nitrogen; ALP — alkaline phosphatase; GGT — γ-glutamyl transferase; ALT — alanine aminotransferase; AST — aspartate aminotransferase.