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Downregulation of SOCS3 by B[a]P-induced miR-650 may be associated with metastatic progression in liver cancer. (A) SOCS3 expression in normal liver tissues and liver cancer tissues. (B) SOCS3 expression in normal liver tissues and varying metastasis-grade liver cancer tissues. (C) Proposed schematic diagram of B[a]P exposure-stimulated miR-650 mediating SOCS3 suppression and JAK activation to promote tumor cell motility and ultimately metastasis of liver cancer.
