Supplementary Table 1.
Hierarchical Clustering of Laboratory Results of All IBD Patients, Vaccinated and Unvaccinated
| Laboratory test/disease activity group | 1 (N =2908) | 2 (N = 10,822) | 3 (N = 2766) | 4 (N = 557) | 5 (N = 141) | 6 (N = 3426) |
|---|---|---|---|---|---|---|
| CRP (mg/dL) | 0.72 ± 1.38 | 0.74 ± 1.15 | 2.96 ± 3.5 | 8.8 ± 7.9 | 21.8 ± 14.1 | — |
| Missing (%) | 902 (31%) | 1979 (18%) | 518 (19%) | 101 (18%) | 16 (11%) | 3426 (100%) |
| ESR (mm/h) | 0.66 ± 0.53 | 0.8 ± 0.7 | 1.44 ± 1.03 | 1.76 ± 1.07 | 3.14 ± 2.09 | — |
| Missing (%) | 2055 (71%) | 7378 (68%) | 1758 (64%) | 360 (65%) | 80 (57%) | 3426 (100%) |
| Platelets (10∗3/μL) | 0.54 ± 0.15 | 0.56 ± 0.12 | 0.7 ± 0.2 | 0.79 ± 0.33 | 0.95 ± 0.54 | — |
| Missing (%) | 31 (1%) | 80 (0.7%) | 12 (0.5%) | 4 (0.7%) | 3 (2.1%) | 3426 (100%) |
| WBC (k/μL) | 0.68 ± 0.19 | 0.65 ± 0.2 | 0.75 ± 0.3 | 0.81 ± 0.52 | 9.03 ± 67.1 | — |
| Missing (%) | 25 (0.9%) | 73 (0.7%) | 9 (0.3%) | 3 (0.5%) | 3 (2.1%) | 3426 (100%) |
| Hemoglobin (g/dL) | 1.18 ± 0.06 | 1.05 ± 0.065 | 0.95 ± 0.1 | 0.86 ± 0.13 | 0.8 ± 0.18 | — |
| Missing (%) | 25 (0.9%) | 73 (0.7%) | 9 (0.3%) | 3 (0.5%) | 3 (2.1%) | 3426 (100%) |
| Albumin (g/dL) | 1.26 ± 0.08 | 1.19 ± 0.07 | 1.09 ± 0.09 | 0.99 ± 0.14 | 0.9 ± 0.18 | — |
| Missing (%) | 314 (11%) | 1740 (16%) | 298 (11%) | 36 (6.5%) | 17 (12%) | 3426 (100%) |
NOTE. Disease activity is ranked from 1 to 5, 1 is mild and 5 is extreme, 6 is no known laboratory results in the 2 years before the vaccination. Count (%) or mean ± standard deviation are presented as appropriate.a
CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; WBC, white blood count.
a
Values were standardized, as appropriate, by dividing the test result by the age and sex adjusted upper/lower normal limit.