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. 2021 Dec 23;18:300. doi: 10.1186/s12974-021-02356-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Effects of SDV on hippocampal TrkB/BDNF signaling in LPS-challenged mice treated with rhANP. a, b Western blot analysis of phosphorylated/total tyrosine kinase receptor B ratio (p-TrkB/t-total) in the hippocampus (one-way ANOVA: F_2,27 = 5.245, P = 0.0119) and prefrontal cortex (PFC) (one-way ANOVA: F_2,27 = 0.2589, P = 0.7738) of mice treated with recombinant human ANP (rhANP) or 0.9% saline 24 h after injection of lipopolysaccharides (LPS) or 0.9% saline. c, d Western blot analysis of p-TrkB/t-total in the hippocampus (two-way ANOVA: rhANP: F_1,36 = 1.633, P = 0.2095; SDV: F_1,36 = 9.169, P = 0.0045; interaction: F_1,36 = 4.395, P = 0.0431) and PFC (two-way ANOVA: rhANP: F_1,36 = 0.1409, P = 0.7096; SDV: F_1,36 = 0.3043, P = 0.5846; interaction: F_1,36 = 0.2733, P = 0.6044) of rhANP or 0.9% saline-treated endotoxemia mice pre-subjected to SDV or sham operation. e, f Western blot analysis of BDNF in the hippocampus (one-way ANOVA: F_2,27 = 12.20, P = 0.0002) and PFC (one-way ANOVA: F_2,27 = 2.218, P = 0.1290) of mice treated with rhANP or 0.9% saline 24 h after injection of LPS or 0.9% saline. g, h Western blot analysis of BDNF in the hippocampus (two-way ANOVA: rhANP: F_1,36 = 6.305, P = 0.0167; SDV: F_1,36 = 2.378, P = 0.1318; interaction: F_1,36 = 5.767, P = 0.0216) and PFC (two-way ANOVA: rhANP: F_1,36 = 0.2615, P = 0.6122; SDV: F_1,36 = 0.1217, P = 0.7292; interaction: F_1,36 = 0.1715, P = 0.6813) of rhANP or 0.9% saline-treated endotoxemia mice pre-subjected to SDV or sham operation. Data are shown as mean ± SEM, n = 10/group. ^*P < 0.05, ^**P < 0.01, ^***P < 0.0001; N.S. not significant. SDV subdiaphragmatic vagotomy