Table 1.

Representative NIR-responsive nano-gas prodrugs and their biomedical applications

Gas	Materials	Tumor cells lines	Therapy	References
NO	RBS-UCNPs GO-BNN6 Me-RBSs Nb2C–MSNs–SNO BNN-Bi2S3 Fe3O4@PDA@Ru-NO@FA PTNGs PNOC-PDA/DOX DTX@m-PB-NO SPNs PFTDPP Lyso-Ru-NO@FA@C-TiO2 L-Arg@PCn@Mem DPP-NF ADAu@CuS YSNPs	Human breast cancer MCF-7/DOXR cells Human osteosarcoma 143B cells Human breast cancer 4T1-LUC cells Mouse breast cancer 4T1 cells Human liver cancer BEL-7402 cells Human cervical carcinoma HeLa cells Human breast cancer MCF-7/ADR cells Human breast cancer MCF-7/ADR cells Mouse breast cancer 4T1 cells Human breast cancer MCF-7 cells Human breast cancer MCF-7 cells Mouse breast cancer 4T1 cells Human cervical cancer HeLa cells Human breast cancer MCF-7/ADR cells	PTT PTT PTT PTT PTT PTT PTT PTT PTT PTT PDT PDT PDT PDT	[73] [74] [75] [76] [77] [78] [79] [80] [81] [82] [83] [84] [85] [86]
CO	m-PB-CO PdNS-CO POM-anchored HMON FeCO-DOX@MC MCM@PEG-CO-DOX PEG@DW/BC CORM@G3DSP-CE6 Uio-BDP-MnCO PB-CO-TPZ PPPPB − CO − Dox NPs NCu-FleCP Fe(CO)5@Au	Human cervical cancer HeLa cells Human lung cancer A549 cells Human malignant glioma U87MG cells Mouse breast cancer 4T1 cells Human colon tumor HCT116 cells Mouse colorectal cancer CT26 cells Mouse breast cancer 4T1 cells Human breast cancer MCF-7 cells Mouse breast cancer 4T1 cells Human breast cancer MCF-7/ADR cells Mouse breast cancer 4T1 cells Mouse breast cancer 4T1 cells	PTT PTT PTT PTT PTT PTT PTT PTT PDT PDT PDT PDT	[87] [88] [89] [90] [91] [92] [93] [94] [95] [96] [97] [98]
H2S	SP-loaded PEG-UCNPs rGO–PEI-DTC AB-DS@BSA-N3 ZnS@ZIF-8	Human breast cancer MCF-7 cells Human breast cancer MCF-7 cells Human laryngeal cancer Hep2 cells Human hepatocellular carcinoma Huh7 cells	PTT PTT PTT PDT	[99] [100] [101] [102]
H2	PdH-MOF mPDAB NPs Z-scheme SnS1.68–WO2.41 UCCZ NPs	Human cervical cancer HeLa cells Mouse breast cancer 4T1 cells Mouse breast cancer 4T1 cells Mouse breast cancer 4T1 cells	PTT PTT PTT PDT	[103] [104] [105] [106]
SO2	DNs–Naph–Cbl RUCSNs-DM Au-Ag-BTS HTNs GNRS@PDA-BTS	Human breast cancer MDA-MB-231 cells Human colon cancer S180 cell Mouse breast cancer 4T1 cells Human breast cancer MCF-7 cells	PTT PDT PDT PDT	[107] [108] [109] [110]