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. 2021 Dec 22;13:231. doi: 10.1186/s13148-021-01209-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — a Change in DNA methylation induced by different durations (3 and 5 months vs. no breastfeeding) of exclusive breastfeeding (EBF) in ALSPAC girls at different ages from birth to 17 years at 5 CpG sites linked to genes in the AMPK pathway. Each curve represents a smooth estimate function (loess estimate) of DNAm variations over time and the confidence bands are the 95% confidence intervals of the smoothed curve. b Change in BMI mediated by DNA methylation at 5 CpG sites linked to genes in the AMPK pathway where DNA methylation is induced by different durations (3,4 and 5 months vs. no breastfeeding) of exclusive breastfeeding (EBF) in ALSPAC girls at different ages from birth to 17 years. Each curve represents a smooth estimate function (loess estimate) of BMI changes over time and the confidence bands are the 95% confidence intervals of the smoothed curve