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. 2021 Dec 23;18:299. doi: 10.1186/s12974-021-02365-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 11 — Identification CD68⁺ and DiI⁺ cells within the lumbar DRGs of WT and Lepr^db/db mice. Sections containing lumbar DRG tissue from WT (A) and Lepr^db/db mice (B) were reviewed to determine the location of CD68⁺DiI⁺ cells. CD68⁺DiI⁺ double positive cells were identified within the DRG, perineural adipose tissue, and meninges surrounding the DRGs. Analysis of the DiI mean signal intensity within the DRG itself revealed a significant difference between WT (n = 3; C) and Lepr^db/db (n = 3; D) mice (p = 0.0167). Images were taken at 20 × and a composite image was formed using the tile scan feature of the Nikon confocal microscope. Scale bar = 100 µm. Error bar represents the standard deviation from three independent measurements