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. 2021 Dec 22;20:240. doi: 10.1186/s12933-021-01426-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Stroke-induced astrocyte response in contralateral striatum of T2D mice is normalized by weight loss. a GFAP immunoreactivity in striatum after sham surgery. b GFAP immunoreactivity fold increase over sham in ipsilateral striatum after tMCAO. c GFAP immunoreactivity fold increase over sham in striatum contralateral to stroke lesion after tMCAO. Data are presented as mean ± SD. Brown–Forsythe and Welch ANOVA followed by Dunnett’s post hoc test; *p < 0.05. d Representative images of GFAP immunoreactivity in contralateral striatum after tMCAO. Group sizes: a non-T2D n = 5, T2D/Ob n = 4, T2D/WL n = 4. b, c Non-T2D n = 3, T2D/Ob n = 3, T2D/WL n = 3