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| hsDHFR variant | AH/AT | ΔEa(T-H) kcal/mol | DADavga (Å) |
|---|---|---|---|
| wild-type hsDHFR | 6.6 ± 0.8 | –0.1 ± 0.1 | 3.05 ± 0.01 |
| F32M | 0.2 ± 0.1 | 2.8 ± 0.2 | 3.20 ± 0.01 |
| F32L | 0.1 ± 0.1 | 6.5 ± 0.3 | 3.48 ± 0.02 |
| F32L-PP26N-PEKN62G | 19.3 ± 6.7 | –0.01 ± 0.2 | 3.10 ± 0.01 |
| Δ62-PEKN | 3.1 ± 0.3 | 0.5 ± 0.1 | 3.10 ± 0.01 |
| Δ26-PPLR-Δ62-PEKN | 5.2 ± 0.5 | 0.1 ± 0.1 | 3.05 ± 0.01 |
From a fit of the data to the model described in ref (41).
