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. 2021 Dec 9;8:692874. doi: 10.3389/fvets.2021.692874

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Copyright © 2021 Greco, Del Prete, De Biase, Palumbo, Albanese, Bruzzese, Carotenuto, Ciani, Tafuri, Meomartino, Mancini, Paciello and Cocchia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mouse testis from control and experimental groups. (A) Testes from mice of the control group showed normal histoarchitecture with uniform, well-organized seminiferous tubules, and complete spermatogenesis. (B) In experimental group 1, no severe and significant alterations were observed in testicular parenchyma nor in spermatogenesis. (C) In experimental group 2, transverse sections of the testis showed scattered mild to moderate alterations, which were present mostly in the multifocal detachment of germinal epithelium, irregular and buckled basement membrane, tubular deformation and degeneration, shrunken seminiferous tubules, and increased luminal diameter. (D) In experimental group 3, mild alterations such as the detachment of germinal epithelium and reduced population of mature spermatozoa are shown. Hematoxylin and eosin, original magnification 40×.